High-Level Resistance to Ceftazidime Conferred by a Novel Enzyme, CTX-M-32, Derived from CTX-M-1 through a Single Asp240-Gly Substitution

A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Cartelle, Monica, del Mar Tomas, Maria, Molina, Francisca, Moure, Rita, Villanueva, Rosa, Bou, German
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2004
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415568/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155242/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.6.2308-2313.2004
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