Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis

The natural diversification of CTX-M β-lactamases led to the emergence of Asp240Gly variants in the clinic that confer reduced susceptibility to ceftazidime (CAZ). In this study, we compared the impact of this substitution on CAZ and ceftazidime-avibactam (CZA) MICs against isogenic Escherichia coli...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ghiglione, Barbara, Rodríguez, María Margarita, Curto, Lucrecia, Brunetti, Florencia, Dropa, Milena, Bonomo, Robert A., Power, Pablo, Gutkind, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971610/
https://ncbi.nlm.nih.gov/pubmed/29632016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00116-18
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