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Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis

The natural diversification of CTX-M β-lactamases led to the emergence of Asp240Gly variants in the clinic that confer reduced susceptibility to ceftazidime (CAZ). In this study, we compared the impact of this substitution on CAZ and ceftazidime-avibactam (CZA) MICs against isogenic Escherichia coli...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Ghiglione, Barbara, Rodríguez, María Margarita, Curto, Lucrecia, Brunetti, Florencia, Dropa, Milena, Bonomo, Robert A., Power, Pablo, Gutkind, Gabriel
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971610/
https://ncbi.nlm.nih.gov/pubmed/29632016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00116-18
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