Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis

The natural diversification of CTX-M β-lactamases led to the emergence of Asp240Gly variants in the clinic that confer reduced susceptibility to ceftazidime (CAZ). In this study, we compared the impact of this substitution on CAZ and ceftazidime-avibactam (CZA) MICs against isogenic Escherichia coli...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Ghiglione, Barbara, Rodríguez, María Margarita, Curto, Lucrecia, Brunetti, Florencia, Dropa, Milena, Bonomo, Robert A., Power, Pablo, Gutkind, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971610/
https://ncbi.nlm.nih.gov/pubmed/29632016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00116-18
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