High-Level Resistance to Ceftazidime Conferred by a Novel Enzyme, CTX-M-32, Derived from CTX-M-1 through a Single Asp240-Gly Substitution

A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directe...

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Bibliographische Detailangaben
Hauptverfasser: Cartelle, Monica, del Mar Tomas, Maria, Molina, Francisca, Moure, Rita, Villanueva, Rosa, Bou, German
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC415568/
https://ncbi.nlm.nih.gov/pubmed/15155242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.6.2308-2313.2004
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