Effects of Ser130Gly and Asp240Lys Substitutions in Extended-Spectrum β-Lactamase CTX-M-9

In CTX-M-9 extended-spectrum β-lactamases (ESBLs), an S130G mutation induced a 40- to 650-fold increase in 50% inhibitory concentrations but decreased hydrolytic activity against cefotaxime. A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q2...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Aumeran, C., Chanal, C., Labia, R., Sirot, D., Sirot, J., Bonnet, R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC182627/
https://ncbi.nlm.nih.gov/pubmed/12937001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.9.2958-2961.2003
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items