Effects of Ser130Gly and Asp240Lys Substitutions in Extended-Spectrum β-Lactamase CTX-M-9

In CTX-M-9 extended-spectrum β-lactamases (ESBLs), an S130G mutation induced a 40- to 650-fold increase in 50% inhibitory concentrations but decreased hydrolytic activity against cefotaxime. A D240K mutation did not modify enzymatic efficiency against ceftazidime. Residue K240 could interact with Q2...

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Detalhes bibliográficos
Main Authors: Aumeran, C., Chanal, C., Labia, R., Sirot, D., Sirot, J., Bonnet, R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC182627/
https://ncbi.nlm.nih.gov/pubmed/12937001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.9.2958-2961.2003
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