Amino Acid Derivatives as Bitter Taste Receptor (T2R) Blockers

In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of structurally diverse bitter compounds. However, only five antagonists or bitter blockers are known. In this study, using molecular modeling guided site-directed mutagenesis, we elucidated the ligand-binding pocket of T2R4....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pydi, Sai P., Sobotkiewicz, Tyler, Billakanti, Rohini, Bhullar, Rajinder P., Loewen, Michele C., Chelikani, Prashen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155672/
https://ncbi.nlm.nih.gov/pubmed/25059668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576975
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