Amino Acid Derivatives as Bitter Taste Receptor (T2R) Blockers

In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of structurally diverse bitter compounds. However, only five antagonists or bitter blockers are known. In this study, using molecular modeling guided site-directed mutagenesis, we elucidated the ligand-binding pocket of T2R4....

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Autors principals: Pydi, Sai P., Sobotkiewicz, Tyler, Billakanti, Rohini, Bhullar, Rajinder P., Loewen, Michele C., Chelikani, Prashen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155672/
https://ncbi.nlm.nih.gov/pubmed/25059668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576975
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