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Amino Acid Derivatives as Bitter Taste Receptor (T2R) Blockers
In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of structurally diverse bitter compounds. However, only five antagonists or bitter blockers are known. In this study, using molecular modeling guided site-directed mutagenesis, we elucidated the ligand-binding pocket of T2R4....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4155672/ https://ncbi.nlm.nih.gov/pubmed/25059668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576975 |
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