A Titratable Two-Step Transcriptional Amplification Strategy for Targeted Gene Therapy Based on Ligand-Induced Intramolecular Folding of a Mutant Human Estrogen Receptor

PURPOSE: The efficacy and safety of cardiac gene therapy depend critically on the level and the distribution of therapeutic gene expression following vector administration. We aimed to develop a titratable two-step transcriptional amplification (tTSTA) vector strategy, which allows modulation of tra...

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Autores principales: Chen, Ian Y., Paulmurugan, Ramasamy, Nielsen, Carsten H., Wang, David S., Chow, Vinca, Robbins, Robert C., Gambhir, Sanjiv S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154804/
https://ncbi.nlm.nih.gov/pubmed/23955099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-013-0673-4
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