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PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation

cAMP-mediated PKA signaling is the main known pathway involved in maintenance of the endothelial barrier. Tight regulation of PKA function can be achieved by discrete compartmentalization of the enzyme via physical interaction with A-kinase anchoring proteins (AKAPs). Here, we investigated the role...

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Detalhes bibliográficos
Main Authors: Radeva, Mariya Y., Kugelmann, Daniela, Spindler, Volker, Waschke, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154725/
https://ncbi.nlm.nih.gov/pubmed/25188285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106733
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