PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate

Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor-α (PPARα) agonists and have been used for several decades as hypolipidemic agents in the clinic. However, contradictory observations exist on the role of fibrates in host response to acute inflammation, with unclear mechan...

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Bibliographic Details
Main Authors: Qi, Yunpeng, Jiang, Changtao, Tanaka, Naoki, Krausz, Kristopher W., Brocker, Chad N., Fang, Zhong-Ze, Bredell, Bryce X., Shah, Yatrik M., Gonzalez, Frank J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Mucosal Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154119/
https://ncbi.nlm.nih.gov/pubmed/25035112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00153.2014
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