Metabolomics Reveals that Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis

To investigate the pathogenic mechanism of ulcerative colitis, a dextran sulfate sodium (DSS)-induced acute colitis model was examined by serum metabolomic analysis. Higher levels of stearoyl lysophosphatidylcholine and lower levels of oleoyl lysophosphatidylcholine in DSS-treated mice compared to c...

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Main Authors: Chen, Chi, Shah, Yatrik M., Morimura, Keiichirou, Krausz, Kristopher W., Miyazaki, Makoto, Richardson, Terrilyn A., Morgan, Edward T., Ntambi, James M., Idle, Jeffrey R., Gonzalez, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276699/
https://ncbi.nlm.nih.gov/pubmed/18249173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.12.003
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