Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface

The huKS-IL2 immunocytokine (IC) consists of IL2 fused to a mAb against EpCAM, while the hu14.18-IL2 IC recognizes the GD2 disialoganglioside. They are under evaluation for treatment of EpCAM(+) (ovarian) and GD2(+) (neuroblastoma and melanoma) malignancies because of their proven ability to enhance...

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Autors principals: Gubbels, Jennifer A. A., Gadbaw, Brian, Buhtoiarov, Ilia N., Horibata, Sachi, Kapur, Arvinder K., Patel, Dhara, Hank, Jacquelyn A., Gillies, Stephen D., Sondel, Paul M., Patankar, Manish S., Connor, Joseph
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153733/
https://ncbi.nlm.nih.gov/pubmed/21792658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1072-9
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