Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

BACKGROUND: MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion mol...

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Autors principals: Belisle, Jennifer A, Horibata, Sachi, Jennifer, Gubbels AA, Petrie, Sarah, Kapur, Arvinder, André, Sabine, Gabius, Hans-Joachim, Rancourt, Claudine, Connor, Joseph, Paulson, James C, Patankar, Manish S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890604/
https://ncbi.nlm.nih.gov/pubmed/20497550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-118
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