Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal carcinoma. The homologous rat gene encodes a 185-amino acid protein that is 88% sequence identical to the aligned 213-amino acid human VHL gene product. When expressed in...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1995
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7604013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6459 |
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