Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

The human VHL tumor suppressor gene has been implicated in the inherited disorder von Hippel-Lindau disease and in sporadic renal carcinoma. The homologous rat gene encodes a 185-amino acid protein that is 88% sequence identical to the aligned 213-amino acid human VHL gene product. When expressed in...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Duan, D R, Humphrey, J S, Chen, D Y, Weng, Y, Sukegawa, J, Lee, S, Gnarra, J R, Linehan, W M, Klausner, R D
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7604013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.14.6459
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