Neutrophil-Mediated Phagocytic Host Defense Defect in Myeloid Cftr-Inactivated Mice

Cystic fibrosis (CF) is a common and deadly inherited disease, caused by mutations in the CFTR gene that encodes a cAMP-activated chloride channel. One outstanding manifestation of the disease is the persistent bacterial infection and inflammation in the lung, which claims over 90% of CF mortality....

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Bibliographic Details
Main Authors: Ng, Hang Pong, Zhou, Yun, Song, Kejing, Hodges, Craig A., Drumm, Mitchell L., Wang, Guoshun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153692/
https://ncbi.nlm.nih.gov/pubmed/25184794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106813
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