Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

Although small-molecule drug discovery efforts have focused largely on enzyme, receptor, and ion-channel targets, there has been an increase in such activities to search for protein-protein interaction (PPI) disruptors by applying high-throughout screening (HTS)–compatible protein-binding assays. Ho...

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Main Authors: Schorpp, Kenji, Rothenaigner, Ina, Salmina, Elena, Reinshagen, Jeanette, Low, Terence, Brenke, Jara K., Gopalakrishnan, Jay, Tetko, Igor V., Gul, Sheraz, Hadian, Kamyar
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2014
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153540/
https://ncbi.nlm.nih.gov/pubmed/24371213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113516861
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