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An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system

Riboswitches are bacterial RNA elements that regulate gene expression in response to metabolite or ion abundance and are considered as potential drug targets. In recent years a number of methods to find non-natural riboswitch ligands have been described. Here we report a high-throughput in vivo scre...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kirchner, Marion, Schorpp, Kenji, Hadian, Kamyar, Schneider, Sabine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552694/
https://ncbi.nlm.nih.gov/pubmed/28798404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07870-w
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