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A High Throughput Screen for Synthetic Riboswitches Reveals Mechanistic Insights into their Function

Riboswitches are RNA-based genetic control elements that regulate gene expression in a ligand-dependent fashion without the need for proteins. The ability to create synthetic riboswitches that control gene expression in response to any desired small-molecule ligand will enable the development of sen...

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Autors principals: Lynch, Sean A., Desai, Shawn K., Sajja, Hari Krishna, Gallivan, Justin P.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858662/
https://ncbi.nlm.nih.gov/pubmed/17317571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.12.008
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