Impaired Eukaryotic Translation Initiation Factor 2B Activity Specifically in Oligodendrocytes Reproduces the Pathology of Vanishing White Matter Disease in Mice

Vanishing white matter disease (VWMD) is an inherited autosomal-recessive hypomyelinating disease caused by mutations in eukaryotic translation initiation factor 2B (eIF2B). eIF2B mutations predominantly affect the brain white matter, and the characteristic features of VWMD pathology include myelin...

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Bibliographic Details
Main Authors: Lin, Yifeng, Pang, Xiaosha, Huang, Guangcun, Jamison, Stephanie, Fang, Jingye, Harding, Heather P., Ron, David, Lin, Wensheng
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152613/
https://ncbi.nlm.nih.gov/pubmed/25186761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1373-14.2014
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