Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

Activation of the glucagon-like peptide-1 receptor (GLP-1R) in pancreatic β-cells potentiates insulin production and is a current therapeutic target for the treatment of type 2 diabetes mellitus (T2DM). Like other class B G protein-coupled receptors (GPCRs), the GLP-1R contains an N-terminal extrace...

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Bibliographic Details
Main Authors: West, Graham M., Willard, Francis S., Sloop, Kyle W., Showalter, Aaron D., Pascal, Bruce D., Griffin, Patrick R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152014/
https://ncbi.nlm.nih.gov/pubmed/25180755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105683
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