Stable Histone Adduction by 4-Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics

[Image: see text] Lipid electrophiles modify cellular targets, altering their function. Here, we describe histones as major targets for modification by 4-oxo-2-nonenal, resulting in a stable Lys modification structurally analogous to other histone Lys acylations. Seven adducts were identified in chr...

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Auteurs principaux: Galligan, James J., Rose, Kristie L., Beavers, William N., Hill, Salisha, Tallman, Keri A., Tansey, William P., Marnett, Lawrence J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151707/
https://ncbi.nlm.nih.gov/pubmed/25099620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja503604t
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