Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...

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Bibliografiske detaljer
Main Authors: Beckmann, Nadine, Sharma, Deepa, Gulbins, Erich, Becker, Katrin Anne, Edelmann, Bärbel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151525/
https://ncbi.nlm.nih.gov/pubmed/25228885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00331
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