Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...

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Main Authors: Beckmann, Nadine, Sharma, Deepa, Gulbins, Erich, Becker, Katrin Anne, Edelmann, Bärbel
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2014
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151525/
https://ncbi.nlm.nih.gov/pubmed/25228885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00331
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