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Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Beckmann, Nadine, Sharma, Deepa, Gulbins, Erich, Becker, Katrin Anne, Edelmann, Bärbel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151525/
https://ncbi.nlm.nih.gov/pubmed/25228885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00331
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