Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...

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Autors principals: Beckmann, Nadine, Sharma, Deepa, Gulbins, Erich, Becker, Katrin Anne, Edelmann, Bärbel
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151525/
https://ncbi.nlm.nih.gov/pubmed/25228885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00331
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