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Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151525/ https://ncbi.nlm.nih.gov/pubmed/25228885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00331 |
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