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Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase
Considering that all natural nucleotides (D-dNTPs) and the building blocks (D-dNMPs) of DNA chains possess D-stereochemistry, DNA polymerases and reverse transcriptases (RTs) likely possess strongD-stereoselectivity by preferably binding and incorporating D-dNTPs over unnatural L-dNTPs during DNA sy...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150803/ https://ncbi.nlm.nih.gov/pubmed/25104018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku709 |
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