The BRCA1-interacting protein, Abraxas, is required for genomic stability and tumor suppression

Germline mutations of BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation of BRCA1 is infrequent in sporadic breast cancers. The BRCA1 protein C-terminus BRCT domains interact with multiple proteins and are required for BRCA1's tumor suppressor functio...

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Main Authors: Castillo, Andy, Paul, Atanu, Sun, Baohua, Huang, Ting Hsiang, Wang, Yucai, Yazinski, Stephanie A., Tyler, Jessica, Li, Lei, You, M James, Zou, Lee, Yao, Jun, Wang, Bin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149256/
https://ncbi.nlm.nih.gov/pubmed/25066119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.050
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