Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

BRCA1 accumulation at DNA damage sites is an important step for its function in the DNA damage response and in DNA repair. BRCA1-BRCT domains bind to proteins containing the phosphorylated serine-proline-x-phenylalanine (pSPxF) motif including Abraxas, Bach1/FancJ, and CtIP. In this study, we demons...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Wu, Qian, Paul, Atanu, Su, Dan, Mehmood, Shahid, Foo, Tzeh Keong, Ochi, Takashi, Bunting, Emma L., Xia, Bing, Robinson, Carol V., Wang, Bin, Blundell, Tom L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747905/
https://ncbi.nlm.nih.gov/pubmed/26778126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.017
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