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The BRCA1-interacting protein, Abraxas, is required for genomic stability and tumor suppression
Germline mutations of BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation of BRCA1 is infrequent in sporadic breast cancers. The BRCA1 protein C-terminus BRCT domains interact with multiple proteins and are required for BRCA1's tumor suppressor functio...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149256/ https://ncbi.nlm.nih.gov/pubmed/25066119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.050 |
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