The BRCA1-interacting protein, Abraxas, is required for genomic stability and tumor suppression

Germline mutations of BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation of BRCA1 is infrequent in sporadic breast cancers. The BRCA1 protein C-terminus BRCT domains interact with multiple proteins and are required for BRCA1's tumor suppressor functio...

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Hlavní autoři: Castillo, Andy, Paul, Atanu, Sun, Baohua, Huang, Ting Hsiang, Wang, Yucai, Yazinski, Stephanie A., Tyler, Jessica, Li, Lei, You, M James, Zou, Lee, Yao, Jun, Wang, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149256/
https://ncbi.nlm.nih.gov/pubmed/25066119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.050
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