Monomethylfumarate Induces γ-Globin Expression and Fetal Hemoglobin Production in Cultured Human Retinal Pigment Epithelial (RPE) and Erythroid Cells, and in Intact Retina

PURPOSE. Sickle retinopathy (SR) is a major cause of vision loss in sickle cell disease (SCD). There are no strategies to prevent SR and treatments are extremely limited. The present study evaluated (1) the retinal pigment epithelial (RPE) cell as a hemoglobin producer and novel cellular target for...

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Bibliographic Details
Main Authors: Promsote, Wanwisa, Makala, Levi, Li, Biaoru, Smith, Sylvia B., Singh, Nagendra, Ganapathy, Vadivel, Pace, Betty S., Martin, Pamela M.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148926/
https://ncbi.nlm.nih.gov/pubmed/24825111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14179
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