Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias

The oncomir microRNA-125b (miR-125b) is upregulated in a variety of human neoplastic blood disorders and constitutive upregulation of miR-125b in mice can promote myeloid and B-cell leukemia. We found that miR-125b promotes myeloid and B-cell neoplasm by inducing tumorigenesis in hematopoietic proge...

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Hlavní autoři: So, Alex Yick-Lun, Sookram, Reeshelle, Chaudhuri, Aadel A., Minisandram, Aarathi, Cheng, David, Xie, Catherine, Lim, Ee Lyn, Flores, Yvette Garcia, Jiang, Shuai, Kim, Jocelyn Tammy, Keown, Christopher, Ramakrishnan, Parameswaran, Baltimore, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148772/
https://ncbi.nlm.nih.gov/pubmed/25006123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-553842
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