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Polo-like kinase 4 inhibition:astrategy for cancer therapy?
In this issue of Cancer Cell, Mason et al. describe development of a Polo-like kinase 4 (Plk4) inhibitor (CFI-400945) with promising activity against tumors formed in mice from patient-derived tumor tissue. A clinical trial has initiated, but questions remain over whether Plk4 is the only relevant t...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148003/ https://ncbi.nlm.nih.gov/pubmed/25117704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.07.017 |
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