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Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

Accurate control of the number of centrosomes, the major microtubule-organizing centers of animal cells, is critical for the maintenance of genome integrity. Abnormalities in centrosome number can promote errors in spindle formation that lead to subsequent chromosome missegregation, and extra centro...

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Sonraí Bibleagrafaíochta
Main Authors: Holland, Andrew J., Lan, Weijie, Niessen, Sherry, Hoover, Heather, Cleveland, Don W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813471/
https://ncbi.nlm.nih.gov/pubmed/20100909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200911102
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