Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates centriole duplication, causing mitotic defects and death of aneuploid cancers. Prior work was substantially extended by showing CFI-400945 causes...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kawakami, Masanori, Mustachio, Lisa Maria, Zheng, Lin, Chen, Yulong, Rodriguez-Canales, Jaime, Mino, Barbara, Kurie, Jonathan M., Roszik, Jason, Villalobos, Pamela Andrea, Thu, Kelsie L., Silvester, Jennifer, Cescon, David W., Wistuba, Ignacio I., Mak, Tak W., Liu, Xi, Dmitrovsky, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828621/
https://ncbi.nlm.nih.gov/pubmed/29434041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719760115
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