Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Bacterial type II CRISPR-Cas9 systems have been widely adapted for RNA- guided genome editing and transcription regulation in eukaryotic cells, yet their in vivo target specificity is poorly understood. Here we mapped genome-wide binding sites of a catalytically inactive Cas9 (dCas9) from Streptococ...

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Bibliografiska uppgifter
Huvudupphovsmän: Wu, Xuebing, Scott, David A., Kriz, Andrea J., Chiu, Anthony C., Hsu, Patrick D., Dadon, Daniel B., Cheng, Albert W., Trevino, Alexandro E., Konermann, Silvana, Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Sharp, Phillip A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145672/
https://ncbi.nlm.nih.gov/pubmed/24752079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2889
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