MUTANT EGFR SUPPRESSION OF MICRORNA-9 INDUCES FOXP1 TO ENHANCE GLIOBLASTOMA TUMORIGENICITY

BACKGROUND: Glioblastoma (GBM) frequently displays amplification and/or mutation of the epidermal growth factor receptor (EGFR) gene. Highlighting the importance of EGFR in the pathogenesis of GBM, aberrant EGFR (ΔEGFR, also known as EGFRvIII) confers a variety of biological effects upon its express...

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Main Authors: Furnari, Frank, Gomez, German, Volinia, Stefano, Croce, Carlo, Zanca, Ciro, Li, Ming, Gutmann, David, Brennan, Cameron, Cavenee, Webster
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144520/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.52
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