Ligand-activated PPAR-γ protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3ε upregulation

BACKGROUND: Thiazolidinediones (TZD) were reported to protect against ischemia-reperfusion (I/R) injury. Their protective actions are considered to be PPAR-γ (peroxisome proliferator-activated receptor γ)-dependent. However, it is unclear how PPAR-γ activation confers resistance to I/R. METHODS AND...

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Hauptverfasser: Wu, Jui-Sheng, Cheung, Wai-Mui, Tsai, Yau-Sheng, Chen, Yi-Tong, Fong, Wen-Hsuan, Tsai, Hsin-Da, Chen, Yu-Chang, Liou, Jun-Yang, Shyue, Song-Kun, Chen, Jin-Jer, Chen, Y. Eugene, Maeda, Nobuyo, Wu, Kenneth K., Lin, Teng-Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144045/
https://ncbi.nlm.nih.gov/pubmed/19221220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.812537
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