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Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPARγ in humans is associated with severe insulin resistance and...
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| Publicat a: | J Clin Invest |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449746/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20964 |
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