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Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPARγ in humans is associated with severe insulin resistance and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC449746/ https://ncbi.nlm.nih.gov/pubmed/15254591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420964 |
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