Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ

Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPARγ in humans is associated with severe insulin resistance and...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Tsai, Yau-Sheng, Kim, Hyo-Jeong, Takahashi, Nobuyuki, Kim, Hyung-Suk, Hagaman, John R., Kim, Jason K., Maeda, Nobuyo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
Fag:
Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449746/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254591/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20964
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