Producing recombinant therapeutic glycoproteins with enhanced sialylation using CHO-gmt4 glycosylation mutant cells

Recombinant glycoprotein drugs require proper glycosylation for optimal therapeutic efficacy. Glycoprotein therapeutics are rapidly removed from circulation and have reduced efficacy if they are poorly sialylated. Ricinus communis agglutinin-I (RCA-I) was found highly toxic to wild-type CHO-K1 cells...

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Main Authors: Goh, John SY, Liu, Yingwei, Chan, Kah Fai, Wan, Corrine, Teo, Gavin, Zhang, Peiqing, Zhang, Yuanxing, Song, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143398/
https://ncbi.nlm.nih.gov/pubmed/24911584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.29490
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