Producing recombinant therapeutic glycoproteins with enhanced sialylation using CHO-gmt4 glycosylation mutant cells

Recombinant glycoprotein drugs require proper glycosylation for optimal therapeutic efficacy. Glycoprotein therapeutics are rapidly removed from circulation and have reduced efficacy if they are poorly sialylated. Ricinus communis agglutinin-I (RCA-I) was found highly toxic to wild-type CHO-K1 cells...

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Hlavní autoři: Goh, John SY, Liu, Yingwei, Chan, Kah Fai, Wan, Corrine, Teo, Gavin, Zhang, Peiqing, Zhang, Yuanxing, Song, Zhiwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143398/
https://ncbi.nlm.nih.gov/pubmed/24911584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bioe.29490
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