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Caspase activation, sialidase release and changes in sialylation pattern of recombinant human erythropoietin produced by CHO cells in batch and fed-batch cultures

The activation of caspases represents a crucial turning point during a batch or a fed-batch culture of mammalian cells. It not only affects the quantity but also the quality of the recombinant glycoprotein produced. In this study, the activation of various caspases, the release of intracellular sial...

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Bibliografiska uppgifter
Huvudupphovsmän: Chuan, Kok Hwee, Lim, Sing Fee, Martin, Laurent, Yun, Chee Yong, Loh, Sophia O. H., Lasne, Francoise, Song, Zhiwei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Kluwer Academic Publishers 2006
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449677/
https://ncbi.nlm.nih.gov/pubmed/19002897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-006-9016-5
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