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Molecular Origin of pH Dependent Fibril Formation of a Functional Amyloid
Fibrils derived from Pmel17 are functional amyloids upon which melanin is deposited. Fibrils of the repeat domain (RPT) from Pmel17 form under strict melanosomal pH (4.5–5.5) and completely dissolve at pH ≥ 6. To determine which Glu residue is responsible for this reversibility, aggregation of singl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4142984/ https://ncbi.nlm.nih.gov/pubmed/24954152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402074 |
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