Efficient Production of Dual Recombinant Adeno-Associated Viral Vectors for Factor VIII Delivery

Recombinant adeno-associated viral (rAAV) vectors have gained attention for human gene therapy because of their high safety and clinical efficacy profile. For factor VIII gene delivery, splitting the coding region between two AAV vectors remains a viable strategy to avoid the packaging capacity limi...

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Detalhes bibliográficos
Main Authors: Wang, Qizhao, Dong, Biao, Firrman, Jenni, Roberts, Sean, Moore, Andrea Rossi, Cao, Wenjing, Diao, Yong, Kapranov, Philipp, Xu, Ruian, Xiao, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142791/
https://ncbi.nlm.nih.gov/pubmed/25093498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.093
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