Evaluation of the biological differences of canine and human factor VIII in gene delivery: implications in human hemophilia treatment

The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

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Détails bibliographiques
Publié dans:Gene Ther
Auteurs principaux: Wang, Qizhao, Dong, Biao, Firrman, Jenni, Wu, Wenman, Roberts, Sean, Moore, Andrea Rossi, Liu, LinShu, Chin, Mario P.S., Diao, Yong, Kost, Joseph, Xiao, Weidong
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936945/
https://ncbi.nlm.nih.gov/pubmed/27064790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.34
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