Evaluation of the biological differences of canine and human factor VIII in gene delivery: implications in human hemophilia treatment

The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Wang, Qizhao, Dong, Biao, Firrman, Jenni, Wu, Wenman, Roberts, Sean, Moore, Andrea Rossi, Liu, LinShu, Chin, Mario P.S., Diao, Yong, Kost, Joseph, Xiao, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936945/
https://ncbi.nlm.nih.gov/pubmed/27064790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.34
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