High-Density Recombinant Adeno-Associated Viral Particles are Competent Vectors for In Vivo Transduction

Recombinant adeno-associated viral (rAAV) vectors have recently achieved clinical successes in human gene therapy. However, the commonly observed, heavier particles found in rAAV preparations have traditionally been ignored due to their reported low in vitro transduction efficiency. In this study, t...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Wang, Qizhao, Firrman, Jenni, Wu, Zhongren, Pokiniewski, Katie A., Valencia, C. Alexander, Wang, Hairong, Wei, Hongying, Zhuang, Zhenjing, Liu, LinShu, Wunder, Stephanie L., Chin, Mario P.S., Xu, Ruian, Diao, Yong, Dong, Biao, Xiao, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178025/
https://ncbi.nlm.nih.gov/pubmed/27550145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2016.055
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